FORMULASI SUSPENSION PDF

Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

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Journal List Adv Pharm Bull v. The viscosity curves showed that the systems were pseudo plastic and thixotrop.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

In Figure 1 the percentage of release in all the formulations are presented. A sample of these curves is shown in Figure 2. Fodmulasi of release for all selected formulations. Please review our privacy policy. Formulation of suspensions One of the methods for making the suspension, is the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: There was no sediment in selected formulations and the sediment volume was 1 for all of them so there was no need for re-dispersion test and the degree of the flocculation was also 1 that was probably because of the high viscosity of the system.

Also the system was found to be time-depended.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

Eur J Pharm Gormulasi. Made formulations are then evaluated for physical stability tests in which the sedimentation volume fkrmulasi ratio of the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio formukasi the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

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Dissolution test For 3 of each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes. According to the viscosity curves, the suspensions were pseudo plastic, i. Considering zuspension sedimentation, the sedimentation volume was determined to be 1. According to these properties a general discussion is presented. Other tests, including measurement of pH, viscosity and zeta potential measurements were performed and finally the best formulations were selected.

An advantage of cefuroxime over other second-generation cephalosporins is that it is effective in the treatment of Neisseria gonorrhea and H influenzae.

One of the methods for making the suspension, is the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: Considering the differences of the viscosity in up and down curves the thixotropy of the system is obvious so the vehicle was pseudo plastic and thixotrop.

For suspension formulation equivalent to mg formylasi cefuroxime was suspended in 5 ml vehicle, after selecting the type and concentration of wetting agent, other ingredients such as flocculating agents, suspending agents, preservatives and flavors were added.

After calculating the viscosity, the curves of viscosity against shear rate were plotted. Conflict of interest The authors report no conflicts of interest. All other chemicals were purchased fromMerck, Darmstadt, Germany. This article has been cited by other articles in PMC.

Pharmaceutical suspensions from formulation to manufacturing. Cefuroxime is the second generation cephalosporin, which its intravenous and oral dosage forms are available. Support Center Support Center.

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Table 2 Results of assay test. This article is based on a thesis submitted for Pharm Dr degree No. According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market.

From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1. Author information Article notes Copyright and License information Disclaimer. Then using equation derived from calibration curve. Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime axetil.

A new approach to HPLC analysis of medicinal suspensions.

Received Aug 28; Accepted Nov Open in a separate window. For the assay solution 5 ml suspeneion suspension was dissolved in 50 ml methanol and after shaking for 5 minutes ml of medium was added and after achieving Port City Press; After selecting the acceptable preparations, physical stability tests and other tests such as dissolution rate, pH, zeta potential and viscosity measurement of formulations were performed.

Acknowledgement The authors would like to thank Dana Pharmaceutical Co. The stability of the amorphous form of cefuroxime axetil in solid state. The charge of the particles effects their distribution in the environment and increases the concentration of opposite charge on the surface close to them which produces electric double layer.

Influence of the soluble solids on the zeta potential of the cloudy apple juice.